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pHIR/P12-1 [pHP/HIR 12.1]
pHIR/P12-1 [pHP/HIR 12.1]
規(guī)格:
貨期:
編號(hào):B233361
品牌:Mingzhoubio

標(biāo)準(zhǔn)菌株
定量菌液
DNA
RNA

規(guī)格:
凍干粉
斜面
甘油
平板


產(chǎn)品名稱(chēng) pHIR/P12-1 [pHP/HIR 12.1]
商品貨號(hào) B233361
Designations pHIR/P12-1 [pHP/HIR 12.1]
GenBank Number

X02160

Species Homo sapiens, human
Depositors A Ullrich
Vector
Construct size (kb): 6.800000190734863
Insert
DNA: cDNA
Insert lengths(kb): 4.099999904632568
Tissue: term placenta
Gene product: insulin receptor [INSR]
Alleles: A4, D1, D2, A2, B1, B2, E2, S1, S2, S3, A3, C2, E1, C1, A1
Insert Size (kb) 4.100
Media ATCC® Medium 1227: LB Medium (ATCC medium 1065) with 50 mcg/ml ampicillin
Biosafety Level 1

Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country.

Shipping Information Distributed: freeze-dried
Comments
Restriction digests of the clone give the following sizes (kb): EcoRI--4.1, 2.7; PvuII--4.0, 2.5, less than 0.5; HindIII--6.8; SalI--6.8; BamHI--3.6, 3.2.
Restriction digests of the clone give the following sizes (kb): BglI--3.7, 1.3, 1.2, 0.78.
The insert extends from the EcoRI site at nucleotide 1013 (amino acid 294) through the 3' untranslated region, including poly(A).
This insert does not encode the cysteine-rich region which is part of the alpha subunit. The insert does encode a portion of the 3' end of the alpha subunit and all of the beta subunit including the transmembrane and tyrosine kinase domains.
A 1.3 kb BglI fragment (12.1B1.3, 1601 - 2963) detects a 3-allele SstI RFLP not detected by the 1.6 kb PstI fragment (12.1P1.6, 2744 - 4343). The BglI fragment encodes the 3' region of the alpha chain and the 5' region of the beta chain.
The 7.0/6.2 kb RsaI polymorphism has been detected with the 1.3 kb BglI fragment probe (12.1B1.3, 1601 - 2963). The polymorphic site maps between nucleotides 1928 and 2478 of the cDNA.
The 2.4/2.2 kb RsaI polymorphism has been detected with the 1.3 kb BglI fragment (12.1B1.3, nt 1601-2963). The polymorphic site maps between nt 2744 and 2963 of the cDNA.
In American Blacks, a 6.4 kb fragment is sometimes (0.6%) detected in RsaI digests. This probably results from another polymorphic RsaI site 0.6 kb from the 7.0 kb fragment.
In Pima Indians, a 3.4 kb fragment is detected (34%) in RsaI digests using the 1.3 kb BglI probe. This probably represents another polymorphic site 3.4 kb from one end of both 6.2 and 7.0 kb fragments.
The SacI site polymorphism (alleles 9.4 kb/7 + 2.4 kb) appears to be private to Caucasian populations (the 7 + 2.4 kb allele detected in only 1/48 Pima Indians and 1/48 American Blacks).
The polymorphic BglII site has been detected using the intact insert or the 1.6 kb PstI fragment (12.1P1.6, 2744-4343). The polymorphic site maps between nucleotides 2744 and 2963 of the cDNA sequence.
References

Patel P, et al. A new Sst 1 RFLP associated with the human insulin receptor locus. Nucleic Acids Res. 16: 5700, 1988. PubMed: 2898769

Radice P, et al. Loss of heterozygosity in human germinal tumors. Cytogenet. Cell Genet. 52: 72-76, 1989. PubMed: 2612217

Ullrich A, et al. Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes. Nature 313: 756-761, 1985. PubMed: 2983222

Elbein SC, et al. Multiple restriction fragment length polymorphisms at the insulin receptor locus: A highly informative marker for linkage analysis. Proc. Natl. Acad. Sci. USA 83: 5223-5227, 1986. PubMed: 3014538

梅經(jīng)理 17280875617 1438578920
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周經(jīng)理 17757487661 1296385441
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沈經(jīng)理 19548299266 2662369050
李經(jīng)理 13626845108 972239479
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